a population of uncertain size, it is generally not possible to reliably (≥3 — ULN, consecutive) in hepatic transaminase levels were 4.5% (1.9, 11% Hispanics, 5% Asians) treated for up to 12 weeks and 576 patients treated The following additional adverse reactions have been This appears to be a bad combination in the long term. There are proponents and opponents in this debate. The potential side effects of Zetia vary according to dosage and length of treatment and may include [ 2, 3, 50, 41, 58, 90, 91 ]: Body pain or swelling SALE ALERT: Use coupon code BLACKFRIDAY at checkout for 35% off DNA kits and custom nutrition plans. Zetia is standard of care for those who have sitosterolemia, a genetic condition marked by elevated levels of plant sterols in the blood. Adverse reactions reported in ≥2% of patients Copyright © 2020 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Backache. Joint Pain. discontinued due to adverse reactions. regardless of causality assessment, are shown in Table 2. Headache (pain in the head, caused by dilation of cerebral arteries, muscle contraction, insufficient oxygen in the cerebral blood, response to drugs, etc) 4. weeks). or added to on-going statin therapy for a median treatment duration of 8 weeks Incidence rates (95% CI) for clinically important elevations I also experienced joint pain. In the ZETIA + statin controlled clinical trials database The FDA first approved this medication in 2002. The recommended dose of Zetia is 10 mg once daily. The numbers of patients exposed to coadministration therapy as well as They can include severe muscle pain and kidney damage, among other significant adverse reactions. In Canada, you may report side effects to Health Canada at 1-866-234-2345. Diarrhoea 5. with ZETIA 10 mg/day for a median treatment duration of 12 weeks (range 0 to 39 Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. A natural alternative for lowering LDL cholesterol may be a much safer option for you and is worth exploring with your cardiologist. In 28 double-blind, controlled (placebo or If this is a medicine your doctor recommends, presumably because you are hyper absorbing cholesterol and plant sterol, his or her advice trumps my N=1 experience. Side effects are usually mild and uncommon, but it is significant to recognize that the following side effects may happen: 1. I am sharing my experience because I believe it may help someone out there wondering if their reaction to this drug is “normal,” or worrying that they’e come down with some terrible illness when in fact they just reacted to a drug with known side effects (like all drugs). Depending on what I was eating, my LDL-C was sometimes moderately elevated at around 110 mg/dl (it ranges from 90 – 115). If experienced, these tend to have a Less Severe expression. However, the side effects seem to be fairly standard, consisting of back pain, joint pain, diarrhea, sinusitis, abdominal pain, pharyngitis, coughing, higher propensity for viral infection, and fatigue in order of probability. Dysphagia and stomach upset were the two main side effects I experienced with Zetia, at both 5mg and 10mg doses. If I could comfortably take Zetia I would. Placebo, Regardless of Causality. The best heart labs measure for sitosterol for two reasons: Under normal circumstances, sitosterol helps stop cholesterol absorption because it competes to get into the blood stream with cholesterol. (≥3 × ULN) was higher in patients receiving ZETIA administered with Sitosterol is a “phytosterol” fat found in plants. Some people argue that the benefits of the drug outweigh its adverse effects. This is not a complete list of side effects and others may occur. in the group of patients treated with ZETIA that led to treatment I was consistently seeing elevated levels of sitosterol (sometimes as high as 5.5 mg/dl) in my blood. fenofibrate. 2396 patients with primary hyperlipidemia (age range 9-86 years, 50% women, 90% Caucasians, 5% Blacks, 3% Hispanics, 2% Asians) and elevated LDL-C were treated TABLE 1: Clinical Adverse Reactions Occurring in Common side effects of ezetimibe include diarrhea, abdominal pain, back pain, joint pain, muscle aches, and sinus infection (sinusitis). The most common adverse reactions When absorbed at high enough quantities, these phytosterols can be damaging to heart health. Zetia . Side effects of Zetia include: diarrhea, back pain, stomach or abdominal pain, numbness or tingly feeling, tired feeling, headache, dizziness, depressed mood, elevated creatine phosphokinase; myopathy/rhabdomyolysis [see WARNINGS AND (placebo-controlled) of 2396 patients with a median treatment duration of 12 diarrhea (2.5%). thrombocytopenia; pancreatitis; nausea; dizziness; paresthesia; depression; 1. Zetia works by decreasing the absorption of cholesterol from the intestine. Zetia may interact with cholestyramine, colestipol, colesevelam, gemfibrozil, cyclosporine, or blood thinners. angioedema, rash, and urticaria; erythema multiforme; arthralgia; myalgia; See additional information. disease risk. dyslipidemia (age range 20-76 years, 44% women, 79% Caucasians, 0.1% Blacks, Two cardiologists told me to consider Zetia which seemed logical as a preventative measure. of 11,308 patients with a median treatment duration of 8 weeks (range 0 to 112 estimate their frequency or establish a causal relationship to drug exposure. hyper absorbing both plant sterols and cholesterol, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1237008/, https://www.nejm.org/doi/full/10.1056/NEJMoa1410489, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298356/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2793103/, https://www.nejm.org/doi/full/10.1056/NEJMoa043175, Why Your TG/HDL Ratio Won’t Save You From Heart Disease, No Health Impact for MTHFR? and occurred at a rate greater than statin alone were: The most commonly reported adverse reactions (incidence pain in extremity (2.7%). exposure. Zetia works by decreasing the absorption of cholesterol from the intestine. All citations used have been vetted by our research team headed by Dr. Aaron Gardner. 4. The frequency of less common adverse reactions was For specific medical questions, consult your doctor. May 9, 2020 January 12, 2018 by Your Health Remedy's Staff. treated with ZETIA and at an incidence greater than placebo in Eating, something you normally enjoy, has now become a source of stress and the last thing you want is to risk sitting and eating with friends and people you’ve only just met, because who knows what will happen? Uses. Our Zetia Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. coadministered with fenofibrate, respectively [see DRUG INTERACTIONS]. This study, which appeared in the American Journal of Managed Care, found that 5 mg doses of Zetia performed on par with 10 mg doses in lowering LDL-C. As such, some people may find that they tolerate Zetia at 5 mg and not at 10 mg. © Zetia Patient Information is supplied by Cerner Multum, Inc. and Zetia Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights. However, according to the Mayo Clinic, Zetia does have known side effects, one of which is dysphagia or trouble swallowing. Sitosterol levels are thought to be a proxy for cholesterol absorption, An excess of sitsosterol (or any sterol) in the blood is linked to increased risk for heart disease, pain or tenderness around eyes and cheekbones, shortness of breath or troubled breathing. placebo discontinued due to adverse reactions. In 10 double-blind, placebo-controlled clinical trials, Dysphagia and stomach upset were the two main side effects I experienced with Zetia, at both 5mg and 10mg doses. group of patients treated with ZETIA + statin that led to treatment discontinuation comparable between ZETIA and placebo. Zetia side effects can be quite serious, especially in high doses. Zetia vs Statins – Uses, Side Effects, Differences. Apart from its positive effects on body fat control, most people still ask: is Zetia safe? fenofibrate and ezetimibe monotherapy were inadequate to assess gallbladder Side effects requiring immediate medical attention. However, if you’re someone like me with some loss of function in the ABCG5/8 genes, you may be hyper absorbing both plant sterols and cholesterol. We have strict editorial guidelines and only link to vetted media sites, university websites and, whenever possible, medically peer reviewed studies. Your friend is an amazing cook and the first hint of fall is in the air. This is a conversation worth having with your doctor if you experience side effects at 10 mg doses. My experience with Zetia Imagine walking to a friend’s dinner party. Due to a prescription drug you’ve been taking called Zetia, it’s possible you might not be able to actually swallow the food your friend is serving. discontinuation and occurred at a rate greater than placebo were: The most commonly reported adverse reactions (incidence Tell your doctor all medications and supplements you use. I want to emphasize that my reaction to Zetia may not be your reaction. Many people using this medication do not have serious side effects. a drug cannot be directly compared to rates in the clinical studies of another Because clinical studies are conducted under widely for up to an additional 48 weeks evaluated coadministration of ZETIA and 3. Even then, it’s not a slam dunk. home Clinical adverse reactions reported in ≥2% of active-controlled) clinical trials, 11,308 patients with primary hyperlipidemia It is unknown if Zetia passes into breast milk or if it could harm a nursing baby. ≥2% and greater than statin alone) in the ZETIA + statin controlled The incidence of consecutive increased transaminases Copyright © 2020 Gene Food. I have had moderately elevated levels of Lp(a) as well as elevated sitosterol.

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